<原著>SLEモデルマウス脾細胞DNAの抗原性と紫外線障害DNAの修復

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概要

• 論文の詳細を見る

• New Zealand Black×New Zealand White F. hybrid mouse (B/W F_1) is a murine model of systemic lupus erythematosus (SLE). Humans and this mouse with SLE, have anti-DNA antibodies, and show an abnormal response to ultraviolet (UV) radiation. We examined the antigenicity of DNA to determine the origin of anti-DNA antibodies and the speed of repair of the UV damaged DNA. DNA was extracted from spleen cells of B/W F_1 and BALB/c (control) mice. Antigenicity of DNA was determined by ELISA. No significant difference in antigenicity of the DNA was found between B/W F_1 and control mice. The ability to repair UV damaged DNA was determined by measurement of priming ability. UV damaged DNA was repaired more rapidly in B/W F_1 mice than in control mice. In conclusion, the DNA from B/W F_1-spleen cells has no particular antigenicity, but UV-induced DNA was repaired more rapidly in B/W F_1 mice.

• 近畿大学の論文
• 1990-12-25

著者

• 山添 康

  近畿大学医学部第3内科学教室

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