<原著>M-SHRSPにおける腎aldosterone受容体の役割
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The author investigated the renal aldosterone receptor (AR) in malignant stroke-prone spontaneously hypertensive rats (M-SHRSP) in comparison with that in normotensive Wistar Kyoto rats (WKY), in order to evaluate the role of AR in the development of hypertension. Blood pressure (BP) was raised at 6 weeks old (wks) and markedly increased thereafter in M-SHRSP. Plasma aldosterone concentration (PAC) did not significantly increase at 6 and 8 wks, but rose at 10 and 12 wks in M-SHRSP. On the other hand, the density of Type I AR (aldosterone specific) in M-SHRSP was significantly higher from 6 wks than that of WKY in accordance with high blood pressure and the increased density of AR continued without apparent difference of dissociation constant (Kd). There were no significant differences in the maximum binding capacity (Bmax) and Kd of Type II (glucocorticoid) AR between WKY and M-SHRSP. The author also observed the increased density of nuclear AR in M-SHRSP compared with WKY. Adrenalectomy did not alter the increased Bmax in M-SHRSP indicating that AR in M-SHRSP is higher independent of PAC. There were no differences in molecular weight and ion charge both of the activated complexes and unactivated complexes between M-SHRSP and WKY, showing that AR function in M-SHRSP is similar to WKY. In addition, the decreases of urinary volume and sodium excretion were observed in M-SHRSP. These results suggest that the increased density of AR in the kidney may enhance aldosterone responsiveness and contribute to the development of high blood pressure in M-SHRSP.
- 近畿大学の論文
- 1989-06-25
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