<原著>気管支喘息におけるglucocorticoid受容体の臨床的ならびに実験的研究
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The relation between the pathological condition of bronchial asthma and glucocorticoid (GC) receptors was investigated by evaluating the GC receptors on human peripheral lymphocytes from asthmatics and guinea pig lung GC receptors in the model of asthma resulting from konjac maiko inhalation. In human experiments, asthma group taking no steroids showed slightly lower maximum binding (Bmax) (20.2±5.9 fmol/10^6cells) than healthy control group (24.0±5.6 fmol/10^6cells) while the steroid group showed lower Bmax value than healthy control by 40% (14.5±4.7 fmol/10^6cells). No significant difference in Bmax was noted between the subgroups classified by type, severity or duration of asthma. In cases treated with prednisolone more than 5mg daily, significant decrease of Bmax than control was observed. Use of theophylline, β-stimulants or antiallergic drugs did not influence Bmax. In healthy control with a few GC receptors, there was a tendency of decreased β-receptors. Correlation was not found between GC receptors and serum cortisol or IgE. Dexamethasone (Dex) was given to non-sensitized guinea pigs to study the relation between the duration of administration and Bmax. Bmax showed the lowest value (81.5±16.2 fmol/mg protein) 6 hours after the administration and reached the peak (234.9±9.9 fmol/mg protein) two days after and then dropped to 103.7±10.2 fmol/mg protein, 29% lower than the value before administration (146.4±11.0 fmol/mg protein), fifteen days after. The combination of Dex and terbutaline sulfate or ketotifen did not influence the lung GC receptors. In the konjac maiko inhalation group, the GC receptor tended to show lower values in 30,60 and 120min after the provocative test than before the test. The group taking Dex alone did not exhibit differences from the Dex-terbutaline or Dex-ketotifen combination group. Responses of GC receptors in human peripheral lymphocytes to various stimuli have been similar to those of guinea pig lung's. The GC receptors of human peripheral lymphocytes are considered to be useful tool in elucidating the mechanism of human bronchial asthma.
- 近畿大学の論文
- 1986-06-25
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