<原著>肺癌の細胞診における細胞型分類
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この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました。From the cytological point of view, exfoliated cells from lung cancer can be classified into 4 groups : squamous cell carcinoma cells, adenocarcinoma cells, small cell carcinoma cells, and large cell carcinoma cells. In this study the relationship between the cytological type as determined by exfoliative cytology and the histological type of the original lesion was investigated. Squamous cell carcinoma cells showed a marked variation in shape and size, and bizarre cells such as "tadpole cells", "fiber cells", and "snake cells", were often seen. Cytoplasmic staining ranged from light green to orange. Irregular nuclear membrans and a marked increase in nuclear chromatin with diffuse hyperchromasia (so called indiaink-like) were often observed. Adenocarcinoma cells were usually round and often found in clusters. Their cytoplasm was clear and stained light green. The nuclei were also round, and the nuclear membrane was often thin and wrinkled. Large nucleoli were the most significant feature in adenocarcinoma cells. Vacuolization, formation of small acini, and papillary arrangements were also often observed. Small cell carcinoma cells were as small as lymphocytes, and consisted almost entirely of nuclei with little or no visible cytoplasm. This type of cell could be differentiated from lymphocytes by their anisocytosis, nuclear hyperchromasia or irregular chromatin pattern. Cells which could not be classified in the above 3 types, were classified as large cell carcinoma cells. These cells had less cytoplasm and a less distinct nuclear membrane. Squamous cell carcinoma was accurately typed in 94.6% of cases, adenocarcinoma in 78.6%, small cell carcinoma in 100%, and large cell carcinoma in 50%. The over-all accuracy of typing was 80%. Further studies are needed on the criteria of large cell carcinoma cells, especially on the differentiation between large cell carcinoma cells and noncornified squamous cell carcinoma cells.
- 1969-03-30
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