<Review Article>Review Transcellular transport of immunoglobulins

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概要

• 論文の詳細を見る

• Recent studies on perinatal transmission of immunoglobulins are reviewed with special reference to the cellular mechanism of IgG transcytosis. Histochemical and cytochemical studies have establised the localization of IgG-specific Fc receptors on the cell surface of the intestinal epithelium or on the endosomal membrane of the syncytiotrophoblast or yolk sac epithelium. A widely accepted scenario of IgG transcytosis is this : Fc receptor specifically binds to IgG molecule to form a complex at pH6 on the cell surface or in the endosome, and the complex moves towards the basolateral cell surface to release the intact IgG molecule into the fetal circulation. Recent in vitro studies revealed a family of GTP-binding proteins and vesicle-membrane fusion proteins involved in the regulation of sorting and transport of IgG, or in the fusion event of IgG-carrying endosomes.

• 山口県立大学の論文

著者

• Ichimura Takao

  School Of Nursing Yamaguchi Prefectural University

関連論文

• Review Transcellular transport of immunoglobulins
• IgG transcytosis is accelerated but its pathway is not disrupted by Brefeldin-A

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