<SESSION>SUMMARY UPDATE OF THE BROOKHAVEN TRITIUM TOXICITY PROGRAM WITH EMPHASIS ON RECENT CYTOGENETIC AND LIFETIME-SHORTENING STUDIES
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概要
- 論文の詳細を見る
A number of years ago a multiparameter program to evaluate the toxicity of tritiated water (HTO) was undertaken in the Medical Department at Brookhaven National Laboratory. The results of most of these studies have been published and will receive brief attention. Emphasis will be placed on the unpublished studies involving the induction of sister chromatid exchanges (SCE's) in bone marrow of mice, new biochemical information, and preliminary results on lietime-shortening and carcinogenesis. In brief, male Hale-Stoner Brookhaven (HSB) mice maintained on HTO concentrations ranging from 3.0 to 30.0 μCi/mi exhibited essentially the same number of SCE's per cell throughout their lifetime. Control mice showed a decrease in number of SCE's with age. The lack of a dose-response effect and the constant level of SCE's in HTO mice as compared to controls will be discussed. In the carcinogenesis study C57BL/6J male mice received various x-ray or HTO regimens. Mortality data from these and other studies in which CBA/Ca/BNL mice received single x-ray exposures or equivalent integrated dose exposures by single HTO injections will be discussed.
- 核融合科学研究所の論文
著者
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Benz R.
Medical Department Brookhaven National Laboratory
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Arland L.
Medical Department, Brookhaven National Laboratory
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Walter P.
Medical Department, Brookhaven National Laboratory
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Ichimasa Yusuke
Ibaraki University
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Ikushima Takaji
Kyoto university
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Tezuka Hideo
National Institute of Genetics
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Ichimasa Yusuke
Ibaraki Univ.
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Arland L.
Medical Department Brookhaven National Laboratory
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Ikushima Takaji
Kyoto Univ. Edu.
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Walter P.
Medical Department Brookhaven National Laboratory
関連論文
- SUMMARY UPDATE OF THE BROOKHAVEN TRITIUM TOXICITY PROGRAM WITH EMPHASIS ON RECENT CYTOGENETIC AND LIFETIME-SHORTENING STUDIES
- Tritium gas oxidizing-bacteria isolated from surface soils and vegetation
- Involvement of G_2 -dependent DSB (double-strand break) Repair in the Formation of UVB-induced Chromosomal Aberrations
- ole of DNA Helicase and Topoisomerase II in the Formation of UVB-Induced Chromosomal Aberrations and Sister Chromatid Exchanges
- Molecular Genetic Study on Mutations in Mitochondrial Genome. 5. Spcctrum Analysis of Hydrogen Peroxide-Induced 16S rRNA Gene Mutations in Chinese Hamster V79 Cells.
- Molecular Genetic Study on Mutations in Mitochondrial Genome. : Mutational Spectrum of 16S rRNA Gene in Chinese hamster V79 Cells
- Preliminary study on a chronic HT release experiment at Chalk River, Canada
- Distribution of tritium into tissue DNA in mice after a long term administration of various tritiated compounds
- Isolation of tritium gas oxidizing actinomycetes with meso-DAP in cell wall from field soils
- Seasonal changes of tritium gas oxidizing airborne bacteria in TPL of Japan Atomic Energy Research Institute
- Isolation of tritium gas oxidizing bacteria from dune soils