<SESSION>CELL DEATH INDUCED IN MOUSE INTESTINE BY TRITIATED WATER, TRITIATED THYMIDINE AND GAMMA RAYS

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Cell death induced by continuous irradiation with gamma rays (externally given by a Cs-137 source) or with beta rays from tritiated water (HTO) injected ip was quantified in the crypts of two portions of mouse bowel, i.e., small intestine (SI) and descending colon (DC). The time-course changes in the incidence of cell death after each type of radiation were studied. For 6-h continuous gamma irradiation with various dose-rates (0.6-480mGy/h) and for 6 h after HTO injection of various radioactivities (0.15-150 GBq per kg body weight), relationships between dose-rate and incidence of cell death were obtained and survival curves were constructed. For the calculation of the absorbed to dose from HTO, water content of the cells was assumed to be 70%. The mean lethal dose-rate i.e., the dose-rate which reduced survival to 37% was calculated for gamma rays and HTO, and RBE of HTO was obtained. The RBE of HTO relative to gamma rays for cell killing in both SI and DC of mouse intestine lies around 1.4-1.6. Tritiated thymidine (^3HTdR) was also injected to mice, and its effects on cell killing were studied.
核融合科学研究所の論文