スナネズミの4つの免疫グロブリンクラスにおけるH鎖定常領域の配列決定

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概要

• 論文の詳細を見る

• We determined partial cDNA sequences of four immunoglobulin (Ig) classes—IgM, IgG1, IgE, and IgA—of Mongolian gerbil (Meriones unguiculatus). Each deduced Ig heavy-chain constant (IGHC) region—Cμ, Cγ1, Cε, and Cα—is structurally similar to its counterparts in the mouse and rat, and phylogenetic analysis suggests that the gerbil Igs are evolutionarily close to their counterparts. In spite of the high sequence homology to the other rodent Cγ sequences, the gerbil Cγ1 sequence differs from our previously reported Cγ2. This result indicates that the gerbil has at least two IgG subclasses. These four gerbil IGHC cDNA sequences will be useful for determining gerbil Ig isotypes and examining the expression of gerbil Ig mRNAs in response to parasitic and bacterial infections.

• 2012-04-01

著者

• Sumiyama Daisuke

  Department Of Animal Science And Resources College Of Bioresource Sciences Nihon University

• Kai Osamu

  Department Of Animal Science And Resources College Of Bioresource Sciences Nihon University

• UKAJI Takao

  Department of Animal Science and Resources, College of Bioresource Sciences, Nihon University

• Ukaji Takao

  Department Of Animal Science And Resources College Of Bioresource Sciences Nihon University

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• スナネズミの4つの免疫グロブリンクラスにおけるH鎖定常領域の配列決定
• Partial sequence of Mongolian gerbil (Meriones unguiculatus) immunoglobulin gamma heavy chain constant region
• Counting Absolute Number of Lymphocytes in Quail Whole Blood by Flow Cytometry
• Use of Genomic In Situ Hybridization to Identify Chromosomes in Gerbil-Mouse Heterohybridomas

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