Effects of Edaravone on a Rat Model of Punch-Drunk Syndrome

スポンサーリンク

概要

• 論文の詳細を見る

• Punch-drunk syndrome (PDS) refers to a pathological condition in which higher brain dysfunction occurs in a delayed fashion in boxers who have suffered repeated blows to the head. However, the underlying mechanisms remain unknown. This study attempted to elucidate the mechanism of higher brain dysfunction observed following skull vibration in two experiments involving a rat model of PDS. Experiment 1 evaluated the effects of edaravone on histological changes in the rat brain tissue after skull vibration (frequency 20 Hz, amplitude 4 mm, duration 60 minutes). The amount of free radicals formed in response to skull vibration was very small, and edaravone administration reduced the number of glial fibrillary acidic protein and advanced glycation end product-positive cells. Experiment 2 examined the time course of change in learning ability following skull vibration in Tokai High Avoider rats. The learning ability of individual rats was evaluated by the Sidman-type electric shock avoidance test 5 days after the last session of skull vibration or final anesthesia and once a month for 9 consecutive months. Delayed learning disability was not observed in rats administered edaravone immediately after skull vibration. These results suggest that free radical-induced astrocyte activation and subsequent glial scar formation contribute to the occurrence of delayed learning disabilities. Edaravone administration after skull vibration suppressed glial scar formation, thereby inhibiting the occurrence of delayed learning disabilities.

• 2011-01-15

著者

• KUROKI Takao

  First Department of Neurosurgery, School of Medicine, Faculty of Medicine, Toho University Sakura Me

• NEMOTO Masaaki

  First Department of Neurosurgery, School of Medicine, Faculty of Medicine, Toho University Omori Med

• HARADA Naoyuki

  First Department of Neurosurgery, School of Medicine, Faculty of Medicine, Toho University Omori Med

• NAGAO Takeki

  First Department of Neurosurgery, School of Medicine, Faculty of Medicine, Toho University Sakura Me

• Nomoto Jun

  Departments Of Neurosurgery Toho University Omori Medical Center

• Nagao Takeki

  Department Of Neurosurgery School Of Medicine Toho University

• Kondo Kosuke

  Department Of Neurosurgery School Of Medicine Toho University

• Kuroki Takao

  Department Of Neurosurgery School Of Medicine Toho University

• Harada Naoyuki

  1st Department Of Neurosurgery School Of Medicine Toho University

• Nemoto Masaaki

  1st Department Of Neurosurgery School Of Medicine Toho University

• Kano Toshiyuki

  1st Department Of Neurosurgery School Of Medicine Toho University

• Nomoto Jun

  First Department Of Neurosurgery School Of Medicine Faculty Of Medicine Toho University Omori Medica

• Kondo Kosuke

  First Department Of Neurosurgery School Of Medicine Faculty Of Medicine Toho University Omori Medica

• Harada Naoyuki

  First Department Of Neurosurgery School Of Medicine Faculty Of Medicine Toho University Omori Medica

• Kuroki Takao

  First Department Of Neurosurgery School Of Medicine Faculty Of Medicine Toho University Sakura Medic

• Nagao Takeki

  First Department Of Neurosurgery School Of Medicine Faculty Of Medicine Toho University Sakura Medic

• Nemoto Masaaki

  First Department Of Neurosurgery School Of Medicine Faculty Of Medicine Toho University Omori Medica

• HARADA Naoyuki

  First Department of Neurosurgery, School of Medicine, Faculty of Medicine, Toho University

• NEMOTO Masaaki

  First Department of Neurosurgery, School of Medicine, Faculty of Medicine, Toho University Omori Medical Center

• KUROKI Takao

  First Department of Neurosurgery, School of Medicine, Faculty of Medicine, Toho University Sakura Medical Center

• NAGAO Takeki

  First Department of Neurosurgery, School of Medicine, Faculty of Medicine, Toho University Sakura Medical Center

関連論文

• Effects of Edaravone on a Rat Model of Punch-Drunk Syndrome
• A case of hypothalamic hamartoma for which fusion image of dual isotope SPECT and MRI was useful for differential diagnosis
• Growth rate of meningioma based on tumor volume
• A case of increased N-isopropyl-p-[^I] iodoamphetamine uptake in primary central nervous system lymphoma : Usefulness of SPECT-MRI fusion imaging
• Development of surgical field camera attachable to an existing shadowless light
• Clinical significance of crossed cerebellar diaschisis in supratentorial brain tumor
• Usefulness of dynamic ^TlCl SPECT for differential diagnosis of ring-enhancing brain lesions
• Prediction of trochlear nerve palsy following surgery for petroclival meningioma : Usefulness of MRI coronal view as preoperative simulation
• Usefulness of neuronavigator for interhemispheric approach to anterior communicating aneurysm : Application for dissection and reconstruction of the frontal sinus
• Disturbed temporal lobe circulation due to compression by pituitary adenoma
• Usefulness of dynamic thallium-201 SPECT in differentiation of tumor recurrence from radiation necrosis
• A pitfall in the statistical analysis of images using three-dimensional stereotactic surface projection (3D-SSP)
• Effects of head inclination on cerebral blood flow assessment using 3D-SSP
• Ruptured Fusiform Aneurysm of the Proximal Anterior Cerebral Artery (A_1 Segment) : Case Report
• Head Trauma in Female Professional Wrestlers
• The extent of the peri-tumoral hypoperfusion area seen by three-dimensional SPECT for malignant glioma
• Evaluation of differences in the registration using the navigation system between operators
• Usefulness of a neuro-navigator for surgical treatment of meningioma
• An integrated three-dimensional image of a brain tumor using thallium-201 SPECT and computed tomography
• Diamox loading ^Tc-HMPAO SPECT by voxel analysis
• Simulation of operation for brain tumors by 3-dimensional MRI
• Usefulness of ^TlCl SPECT for the evaluation of intratumoral embolization : Analysis by dynamic SPECT
• Cranial Nerve Pareses Following Wrapping of a Ruptured Dissecting Vertebral Artery Aneurysm : a Possible Complication of Cyanoacrylate Glue
• Neurosarcoidosis Without Systemic Sarcoidosis
• HEPATIC ARTERIAL INFUSION CHEMOTHERAPY FOR LIVER METASTASIS
• CLINICAL EXAMINATION OF HEPATOCELLULAR CARCINOMA TREATED AT THE DEPARTMENT OF SURGERY, PUBLIC FUJIOKA GENERAL HOSPITAL
• Effects of Edaravone on a Rat Model of Punch-Drunk Syndrome
• A comparative study of the anatomy of rat and human livers
• Modified Three-Dimensional Brain Model for Study of the Trans-sylvian Approach
• Normal Form of Nonlinear Schrodinger Equation
• Usefulness of preoperative three-dimensional rotational digital subtraction angiography for superficial temporal artery to middle cerebral artery bypass
• A case with recurrent giant falcotentorial meningioma resected totally by using the postoperative brain contusion
• Three-dimensional fusion image of digital subtraction angiography and single photon emission computed tomography
• Usefulness of a neuronavigation system in neck clipping of distal anterior cerebral artery aneurysm

もっと見る 閉じる

スポンサーリンク