第一遷移元素を活用するヘテロアレーン類の炭素-水素結合直接変換反応の開発 : 銅およびニッケルの利用

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Over the last decade, transition-metal-mediated or -catalyzed reactions involving a C-H bond cleavage have received much attention and grown rapidly because of their possibility for transformation of ubiquitous C-H bonds into the versatile functions in one synthetic operation. These methodologies are now applied to the direct functionalization of heteroarenes, which are prevalent in pharmaceutical and material sciences, and provide a potentially more efficient alternative to the conventional cross-coupling strategies with halogenated or metalated heterocycles. However, most reported procedures rely on the precious metal catalysts such as palladium, rhodium, and ruthenium. Recently, we have focused on the inherent catalytic activity of less expensive first transition elements and succeeded in the copper- and nickel-promoted direct C-H arylation, alkynylation, and amination reactions, which are reported herein.
2011-03-01