外部刺激によるロタキサン類の分子運動制御

概要

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Noncovalent interactions sometimes play critical roles in restricting molecular dynamics. Rotaxanes that contain two or more recognition sites in one of their components can exist as two or more different translational isomers. Regulating the motion of these isomers, or the association and dissociation of pseudorotaxanes, in response to external stimuli is an attractive challenge because such switching systems would aid the development of molecular devices, sensors, drug delivery systems, and so on. Many molecular switch systems based on (pseudo) rotaxane respond to external stimuli, including chemical additives, pH, solvent polarity, light, electrochemical reduction and oxidation, and temperature. This review focuses on mechanisms of the translational isomerism and the association and dissociation of pseudorotaxanes: regulation of interactions between two or more components caused by the provisional changes of functional groups and the changes in three-dimensional structures of the molecules.
2011-01-01