Long-term Results of High-dose-rate Brachytherapy and External-beam Radiotherapy in the Primary Treatment of Endometrial Cancer
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In this report we update our long-term follow-up results of the prospective study whose aim was to evaluate the efficacy of high-dose-rate (HDR) brachytherapy in combination with external-beam radiotherapy (EBRT) in the treatment of medically inoperable endometrial cancer. Between 1995 and 1998, 29 patients with stages I-III medically inoperable carcinoma of endometrium were treated with definitive irradiation. All patients underwent combined intracavitary HDR brachytherapy and EBRT. The EBRT dose was 50 Gy with midline shield from 16 Gy. The HDR brachytherapy dose was 50 Gy, delivered in 5 fractions in a weekly schedule. Overall survival (OS) at 5 and 10 years was 48.3% and 20.7%, respectively. Disease-specific survival (DSS) at 5 and 10 years was 73.5% and 67.9%, respectively. The 10-year DSS rate was 73.5% for all stages, 85.7% for Stage I disease, 71.4% for Stage II, and 16.7% for stage III disease. Late Grade 1–2 radiation complications were observed in 4 patients (13.8%). Our long-term follow-up confirms that HDR brachytherapy with EBRT appears to be an effective and safe treatment for stage I and II medically inoperable endometrial cancer.
- 2010-11-16
論文 | ランダム
- 水環境における栄養塩・有機物の動態に関する研究と市民による水環境調査への展開
- 長期的な環境モニタリングの重要性とその体制整備
- 閉鎖湖沼(四尾連湖)における物質収支 (陸水学会第66回大会:集水域の生物地球化学 課題講演記録 集水域の生物地球化学:その意義と展望)
- 市民参加の学会へ
- 都市河川はきれいになったか 水質の変遷と河川環境の再生