四重極質量分析計から四重極イオントラップ-飛行時間ハイブリッド型装置に至る質量分析装置の開発とその普及

概要

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The success of on-line combinations of mass spectrometers with chromatography has helped to spread mass spectrometers. Currently, several types of mass spectrometers are commercially available. Among these, quadrupole mass spectrometers are most commonly used. The basic principle of quadrupole mass spectrometers is easily described mathematically. However, there are several technical problems which must be overcome to realize a truly practical instrument, better enabling mass production. Here, we introduce two technologies that we have developed at Shimadzu. One is the electrode configuration to reduce mass discrimination caused by the exit fringing field. The other is a method of peak shape improvement using unstable bands which are generated by modulating quadrupole fields. The principle of unstable band generation inside a stable band is briefly described. Experience and understanding acquired through the development of quadrupole mass spectrometers are the technical basis for the subsequent development of radio frequency drive ion optical devices. We also briefly introduce the ion optical devices which we have developed and applied to commercial instruments.
2009-02-01