人工内耳動物モデルにおける聴覚系の変化 : 形態学的研究(臨床症例との検討を加えて)

概要

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It is now recognized that normal effect innervation is necessary for development of the auditory pathway. This study investigated the effect of chronic electrical stimulation of the auditory nerve on the size of cochlear nucleus somata of neonatally deafened kittens. Total 16 kittens were deafened by using kanamycin and ethacrynic acid at 10 days of age and implanted at various ages (60-719 days) with an active intracochlear implant in the left side and some of them chronically and electrically stimulated from ages 98- 665 days. Then the kittens were investigated the soma area of cochlear nucleus and the 2 deoxyglucose (DG) uptake area on the inferior colliculus. The soma area of 2 DG-labeled regions was usually larger than that of the unlabeled regions up to the stimulation starting time of 140 days significantly, but the area of 2 DG labeled regions of the inferior colliculus was larger up to 180 days in either stimulated and unstimulatred kittens. This means that electrical stimulation of the auditory nervous system is very effective even the ages of 140- 240 days and there appears to be optimum age for cochlear implantation.
日本耳科学会の論文
1999-05-25