Preparation and Characterization of Spherical and Baloon-Like Calcium Phosphate Particles

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概要

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• Calcium phosphate particles were prepared by aging a solution dissolving CaCl_2 and sodium triphosphate(sodium tripolyphosphate, Natpp: Na_5P_3O_10)at 100-150℃ for 16h in a Teflon-lined screw-capped Pyrex test tube. The rod-like and spherical particles were precipitated with an extremely fast rate of reaction under 100℃. The spherical particles were only produced in a very narrow region at 100℃ by aggregation of primary small particles. The rod-like particles were Ca_2P_2O_74H_2O but the uniform spherical ones were amorphous and the latter ones were crystallized to β-Ca_2P_2O_7 after calcined above 600℃. The aging temperature drastically varied the particle shape under a condition for producing uniform spherical particles; solid spherical particles were produced up to the aging temperature of 115℃ but balloon-like hollow spheres were precipitated at 120℃. However, large and irregular agglomerates that are made up of extremely small rod-like particles were precipitated after aging the solution above 125℃. TEM observation and ICP-AES measurements revealed that the balloon-like hollow spheres were produced by dissolving the interior of solid spherical particles after reinforced their shell by the adsorption of tpp unhydrolyzed. The spherical and balloon-like calcium phosphate particles with amorphous crystal form showed a high selective adsorption of H_2O by rehydration of Ca＾2+ ions by penetrated H_2O molecules into the particles. Especially, the balloon-like hollow spheres of calcium phosphate may hold potential as drug delivery vehicles and have biocompatibility advanteges.

• 2008-12-15

著者

• KANDORI Kazuhiko

  School of Chemistry, Osaka University of Education

• Morisada Yoshiaki

  Department Of Processing Technology Osaka Municipal Technical Research Institute

• TADA Kiri

  School of Chemistry, Osaka University of Education

• FUKUSUMI Masao

  Department of Processing Technology, Osaka Municipal Technical Research Institute

• Tada Kiri

  School Of Chemistry Osaka University Of Education

• Fukusumi Masao

  Department Of Processing Technology Osaka Municipal Technical Research Institute

• Kandori Kazuhiko

  School Of Chemistry Osaka University Of Education

関連論文

• Preparation and Characterization of Spherical and Baloon-Like Calcium Phosphate Particles
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• Adsorption of CO_2, CH_3OH, and H_2O on Fe(III)-Substituted Calcium Hydroxyapatites
• Production of Sheet-Like Hydroxyapatite Particles Using a Microreactor

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