Splenic Inflammatory Pseudotumor : Inflammatory Myofibroblastic Tumor

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概要

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• We report a case of a splenic inflammatory pseudotumor (myofibroblastic tumor) in a 43-year-old man with a 5-year history of chronic bronchitis and sleep apnea syndrome. The patient was hospitalized because of a screen-detected splenic mass lesion. His sputum cultures revealed Mycobacterium avium complexes on only one occasion. Imaging studies revealed a 7 cm solitary tumorous lesion, and differential diagnoses of splenic hamartoma, hemangioma, lymphoma, and angiosarcoma were obtained from the radiologist. A splenectomy followed by pathological investigations was performed. By histology, the lesion contained fibroblastic or myofibroblastic spindle cell proliferations, accompanied by variable degrees of inflammatory cell infiltration. Ziehl-Neelsen staining did not reveal acid-fast bacteria. Immunohistochemically, the fibroblastic or myofibroblastic spindle cells were positive for vimentin, human smooth muscle actin, and muscle actin, but negative for desmin, CD8, CD21, CD23, CD35, p80, Epstein-Barr virus LMP, and human herpesvirus type 8. The infiltrating lymphoid cells demonstrated a nonneoplastic pattern. The results of in situ hybridization for Epstein-Barr virus encoded RNA were negative. The postoperative course was uneventful and he has had no recurrence in 22 months. His sleep apnea syndrome and chronic bronchitis have resolved spontaneously since the splenectomy. [J Clin Exp Hematopathol 47(2) : 83-88, 2007]

• 日本リンパ網内系学会の論文
• 2007-11-01

著者

• Inayama Yoshiaki

  東海大学 医学部病理診断学

• Inayama Yoshiaki

  Division Of Anatomical And Surgical Pathology Yokohama City University Hospital

• Oshiro Hisashi

  Department Of Pathology Yokohama City University School Of Medicine

• Inayama Yoshiaki

  First Department Of Pathology Yokohama City University School Of Medicine

• Yamanaka Shoji

  Division of Pathology, Yokohama City University Graduate School of Medicine

• Sakamoto Yasunari

  横浜市立大学 医学研究科消化器内科

• Yamanaka Shoji

  横浜市立大学 医学部外科治療学

• Yamanaka Shoji

  Department Of Surgery Yokohama City University School Of Medicine

• Yamanaka Shoji

  横浜市立大学 医学研究科分子消化管内科学

• Yamamoto Shogo

  東京大学先端科学技術研究センター ゲノムサイエンス分野

• NOMURA Masato

  Department of Biotechnology and Chemistry,School of Engineering,Kinki University

• Yamanaka Shoji

  Department Of Pathology Yokohama City University

• Inayama Yoshiaki

  Division Of Anatomic And Surgical Pathology Hospital Of Yokohama City University Yokohama City Unive

• Inayama Yoshiaki

  Department Of Pathology Yokohama City University

• WATANABE SHINICHIRO

  Department of Gastroenterology, Tokyo Women Medical College

• OSHIRO Hisashi

  Division of Anatomic and Surgical Pathology, Yokohama City University Hospital

• Yamanaka Shoji

  Division Of Anatomic And Surgical Pathology Hospital Of Yokohama City University

• Inayama Yoshiaki

  Division Of Anatomic And Surgical Pathology Yokohama City University Hospital

• Yamanaka Shoji

  Division Of Anatomical And Surgical Pathology Yokohama City University Hospital

• Oshiro Hisashi

  Department Of Pathology Yokohama City University Hospital

• Nomura Masato

  Department Of Biotechnology And Chemistry School Of Engineering Kinki University

• Inayama Yoshiaki

  Division Of Anatomic And Surgical Pathology Hospital Of Yokohama City University Yokohama City Unive

• Watanabe Shinichiro

  Department Of Gastroenterology Tokyo Women's Medical College

• Watanabe Shinichiro

  Department Of Clinical Laboratories Yokohama City University Hospital

• Nomura Masato

  Department Of Gastroenterological Surgery Yokohama City University Hospital

• Inayama Yoshiaki

  Division Of Anatomic And Surgical Pathology Hospital Of Yokohama City University Yokohama City University School Of Medicine

• Nomura Masato

  Department Of Biotechnology And Chemistry Faculty Of Engineering Kinki University

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