NIH, Jacobson 研究室に留学して
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概要
- 論文の詳細を見る
Here I report my projects at Dr. Jacobsons laboratory in National Institutes of Health. Conformationally locked nucleotides, <I>N</I>-methanocarba analogs and oxabicyclo [2, 2, 1] heptane analog, were prepared for hP2Y<SUB>1</SUB> receptor. The most potent molecule is an <I>N</I>-methanocarba <I>N</I><SUP>6</SUP>-methyl-2-iodo analogue (MRS-2500), which is the most potent antagonist selective for the P2Y<SUB>1</SUB> receptor yet reported. I also succeeded in identifying the pairs of neoceptor-neoligand, which are pharmacologically orthogonal with respect to the native species.
- 社団法人 有機合成化学協会の論文
- 2006-06-01