海洋産ポリ環状エーテル, シガトキシン類の合成研究
スポンサーリンク
概要
- 論文の詳細を見る
More than 20, 000 people suffer annually from ciguatera seafood poisoning in tropical and subtropical areas. The principal causative agents, ciguatoxin and its congeners CTX3C and 51-hydroxyCTX3C are extremely potent neurotoxins that bind to voltage-sensitive sodium channels. The extremely limited availability of these ciguatoxins has hampered the detailed biological studies and preparation of anti-ciguatoxin antibodies for detecting these toxins. Therefore the supply of these compounds by the chemical synthesis has been strongly demanded. Furthermore the unique structural features have attracted the attention of the synthetic chemists. This review has briefly focused on the synthetic studies of ciguatoxins in a convergent manner including a total synthesis.
- 社団法人 有機合成化学協会の論文
- 2006-04-01
著者
関連論文
- 26 ガンビ***ールの合成研究(口頭発表の部)
- 41 ポリ環状エーテルの収束的合成とガンビ***ール全合成への応用(口頭発表の部)
- ブレベトキシンBの全合成
- P-31 ブレベトキシンBの全合成(ポスター発表の部)
- 37(D-7) ブレベトキシンBの合成研究(口頭発表の部)
- 海洋産ポリ環状エーテル, シガトキシン類の合成研究