薬物代謝におけるMSを用いた代謝物の構造解析とその代謝経路の究明

概要

論文の詳細を見る
The aim of drug metabolism study is to elucidate the phenomena associated with the efficacy or the toxicity of a drug by tracing its biotransformation after administration to an organism. The structure determination of metabolites in plasma, urine and bile and the clarification of metabolic pathways have been considered as the important tasks indispensable to the development of a new drug. However the structure determination is not a final object, but the investigation of pharmacological activity of determined metabolites and species differences in metabolism is important for application of the drug candidate to human. In particular, mass spectrometry (MS) has played a major role in this field.This study explained two examples of such elucidation of chemical structure of metabolites and metabolic pathways using MS. In the structural elucidation of metabolites, the most suitable ionization method should be selected for each drug and metabolite from various ionization modes of EI, FAB, and ESI.
日本質量分析学会の論文
1998-06-01