食餌療法による成長期の虚弱脛骨骨端, 骨幹端の変化に関する X 線学的および病理組織学的研究
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Experimental osteoporosis was induced by calcium deficient diet in 3 week-old Wistar rats. Standard diet and mixture of sardine powder and standard diet (1 : 2) was supplemented in control and experimental groups respectively for 8, 9 and 10 weeks. Proximal tibia was investigated radiographically and histhopathologically. The results were as follows. I. Radiographic findings 1. Tibia epiphysis in experimental group was shown to be well shaped compared with control group. The compact bone was thickened and bone surface leveled. Trabeculae increased and regularly oriented. 2. Metaphysis in experimental group showed that trabeculae were increased and densly arranged compared with control group. II. Histopathologic findings 1. Contact microradiogram a. Epiphysis Compared with control group, granulated trabeculae of primary spongiosa in experimental group were shown to be reduced at 9th and 10th week postexperimentally, and those of secondary spongiosa increased and thickened. b. Metaphysis Granulated trabeculae of primary spongiosa were shown to be decreased from 9th week postexperimentally, while those of secondary spongiosa increased in amount, more thickened and more radiopaque. 2. Histopathologic findings a. Epiphysis Some changes were present in chondrocyte layer 8, 9, and 10 weeks after the study started in experimental group. Mineralized matrix corrosion by chondroclasts was expanded and subchondral ossification increased in both control and experimental groups. b. Metaphysis As in contorl group, the number of chondrocyts in proliferative and hypertrophic layers decreased 8 and 9 weeks postexperimentally. In experimental group, corrosion of mineralized matrix within inter-chondrocytic spaces, which was induced by chondroclasts in hypertrophic layer, increased and endochondral ossification was revealed abundant. Considering the foregoing results, continued supplementation with mixture of sardine powder was able to facilitate in the endochondral ossification as a dietary therapy for bone loss.
- 九州歯科学会の論文
- 1998-06-25