虚弱下顎骨骨欠損の治癒機転におけるカルシトニン療法に関する実験的研究
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概要
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Six-week-old male Wistar rats were maintained on a low-calcium diet and mandibular bone debility was induced in them. The rats suffered defects of the alveolar bone and were given eel calcitonin (ECT). These specimens were inspected at 3, 7, 14, and 28 days after the operation. The results were as follows : 1. Body weight No difference was found in the body weight between the control group and other experimental groups in 14 days and 28 days after operation (p>0.05). 2. Analysis of radiological bone shadow density The equivalence of bone shadow density decreased in the following order : the control group, the standard diet and ECT group, the standard diet group, the low-calcium diet, standard diet and ECT group, the low-calcium diet and standard diet group. These experimental groups showed low values as compared with the control groups (p<0.01). 3. Histopathological findings As compared with the control group, wider expansion of bone marrow, higher decrease in bone quantity and also delayed healing of the defects were observed in the low-calcium diet and standard diet groups. In the low-calcium diet, standard diet and ECT groups an accelerated active osteoid bone formation was observed on the cancellous tissue of the defect. On the basis of the foregoing results, in the calcitonin administered rats, active periosteal reaction was seen in the degree of wound healing in the early stages. It was suggested that calcitonin might accelerate the healing for the defect of alveolar bone debility. 4. Hematologic findings No significant differences in the electrolytes test were found among the control group and all other experimental groups. Approximate normal values were shown. In the blood chemistry test, the ALP of the low-calcium diet and standard diet group had a retarded ascent compared with the standard diet group, and the standard diet and ECT group. In an approximate ALP of the low calcium diet, standard diet and ECT group, the same ascent time was shown with the standard diet group, and the standard diet and ECT group. It also showed high values as compared with the low-calcium diet and standard diet groups (p<0.05).
- 九州歯科学会の論文
- 1998-02-25