低カルシウム食若年期の食餌療法における下顎骨の変化に関する実験的研究 : 骨基質形成について
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概要
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The most apparent changes take place in living organism during childhood, especially the adolescent years. The author reported the results of the study on bone formation, after 3 week of supplementation with calcium-balanced standard diet, of mandibular bone loss derived from 3-week feeding of calcium-deficiency and 20% low-calcium dietary, using male Wistar rats of adolescent age. 1. Body weight The body weight were shown nearly twofold increase at 6th week post-experimentally over at the beginning in control, calcium deficiency, and low calcium group. Calcium-deficiency group showed significantly higher weight than control group (p<0.05). 2. Bone density Control group showed significantly higher density than the experimental groups (p<0.05). Calcium-deficiency group showed decreased value among the experimental groups (p<0.05). 3. X-ray microanalysis findings The area analysis of calcium and phosphorus distribution was done to investigate the characteristic radiographic density. The density of calcium was shown to be higher than that of phosphorus in all the control and experimental groups, by the area analysis of distribution of Ca and P within the mandible. 4. Pathological findings Calcium-deficiency group showed decreased bone thickness. Remodelling layers were identified through all the bone layers, osteocytic lacunae decreased, and undermineralized layers scattered in lamellar bone. 20% Low-calcium group showed markedly increased bone thickness, almost the same as control group, and adundant and regular distribution of osteocytic lacunae, in contrast to calcium deficiency group. 5. SEM findings Compared with control group, calcium-deficiency group showed more increased resorptive area than rest area. Amorphic osteocytic lancunae increased, and boundary with surrounding matrix was indistinct. In 20% low-calcium diet group, the resorptive areas were overtaken by the bone formative area, which was different from in calcium-deficiency group. Formtive areas of bone matrix, covered superficially with densely arranged collagenogenic fibrils, were demonstrated to expand, with osteocytic lacunae embedded by regularly arranged collagenous fibrils. 6. Hematological findings No significant differences were found among the three group with reference to the electrolytic and biochemical examination. Endocrinal examination showed nonrewarding. As indicated above, the long-term supplementation of standard dietary would help with bone recovery on the bone loss resulted from 20% low calcium intake in adolescence years, as long as the peak bone mass was well obtained before.
- 九州歯科学会の論文
- 1997-12-25
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