抗原投与経路の違いによる抗ミュータンス群レンサ球菌唾液 IgA の誘導効率の相違
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概要
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Recent reports showed that the tonsillar application of sheep red blood cells (SRBC) is an effective method to induce specific IgA in saliva. In the case of tonsillar application, the level of anti-SRBC antibody in saliva of the rabbits was much higher than those in the case of oral and nasal administration. The purpose of this study is to examine the efficiency of the salivary antibody induction using formalin-killed Streptococcus mutans or Streptococcus sobrinus, instead of SRBC. Sixth week after the immunization by tonsillar and nasal application, anti-S. mutans or anti-S. sobrinus agglutination titers of saliva and blood plasma greatly increased. Anti-S. mutans or anti-S. sobrinus IgA concentration in saliva after the application also increased at the sixth week. In the case of tonsillar application, both the level of agglutination titer and IgA concentration in saliva against S. mutans and S. sobrinus were four times higher than those in the case of nasal application. The numbers of IgA-producing cells against S. mutans and S. sobrinus were the highest in submandibular glands among those in the lymphoid tissues including parotid glands, intestinal mucosa, nasal mucosa, and spleen. In the case of nasal application, the number of these cells was the highest in nasal mucosa. The results show that tonsillar application is more effective method to induce anti-mutans streptococci IgA in saliva than nasal application.
- 九州歯科学会の論文
- 1997-12-25