若年期虚弱骨における食餌療法に関する実験的研究 : 脛骨骨幹皮質骨について
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The bone formation proceeds with balance in maxillofacial, skull and long bones during development in childhood. The absorption rate of calcium within intestine has a tendancy to get higher during early childhood in rat, corresponding to the adolescence, or secondary sex characteristics stage, in human. However, the related studies have not been reported. Here the author presented the report on changes in bone structure after the standard diet feeding in place of calcium-deficient and calcium low-deficient diet, with which bone debility was induced experimentally in male Wistar rats of 8 weeks old. The results were as follows. 1. Body weight There was not significant difference among the control group, calcium-deficient → standard diet group and calcium low-deficient → standard diet group. 2. X-ray findings Compared with control group, calcium-deficient → standard diet group showed diaphyseal cortex formed more thinly. Calcium low-deficient → standard diet group, however, maintained the radiopaque appearence of diaphyseal cortex almost unchanged, and so did the control group. 3. X-ray findings on bone density The significant differences of diaphyseal cortical density were demonstrated between the calcium-deficient → standard diet group and control group (p<0.01), as well as between calcium low-deficient → standard diet group and control group (p<0.05). 4. Hematologic findings No significant differences were shown among the three groups in such parameters as serum Ca, P, Ca/P, Na, K, Cl, and GOT, GPT, LDH, CPK, ALP (p<0.05). 5. Histopathologic findings Compared with the control group, the diaphyseal cortex showed decrease of Harversian system, incomplete Harversian canal, bone resorption, and decrease of bone lacunac in calcium-deficient → standard diet group. While the whold layer of diaphyseal cortex in calcium low-deficient → standard diet group recovered to almost the same appearanco as in control group. 6. Scanning electron microscope findings There were not any morphological changes shown in the two experimental groups. compared with the control group. In calcium-dificient → standard diet group, the resorptive layer was shown more extensively than the rest layer. However, the calcium low-deficient → standard diet group was shown more extensive rest layers, abundant collagen fibrils with certain direction in the osteogenetic layer, interlocked and tallied collagen fibrils, and bone formation. On the basis of foregoing findings, for bone debility in growth stage derived from calcium-deficiency, the bone formation would be recovered sufficiently with balanced calcium diet therapy, even though not combined with supplemental active Vitamin D_3, PTH or calcitonin.
- 1997-08-25
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