実験的歯の移動が Streptozotocin 誘発糖尿病ラットの臼歯歯髄内神経線維に及ぼす影響

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In order to evaluate the response of the pulp nerve fibers to diabetes mellitus, 8-week-old male Wistar rats were used. 4 weeks after injection of Streptozotocin (STZ), the upper 1st molars of rats were moved in mesial direction by use of wire springs with about 15g orthodontic force for 1, 3, 7 and 14 days. The histological specimens were investigated by light microscopy. The results were as follows : 1. In the group without orthodontic appliance, there was no distinct difference in pathological findings of the pulp except neurohistological findings between the healthy group and the diabetic group, but the number of osteoclasts existing on the distal root side of alveolus in the healthy group was more than that in the diabetic group. Neurohistologically, degeneration in the pulp nerve fibers gradually advanced through the periods of observation in the diabetic group. 2. In the group with orthodontic appliance, the patterns of tooth movement, which included "Intrusion of mesial root" and "Extrusion of distal root", were similar in both healthy group and diabetic group. Following these tooth movements, there was no distinct difference in pathological findings of the pulp except neurohistological findings in both groups. Neurohistologically, the pulp nerve fibers revealed more severe degeneration day by day in the diabetic group than that in the healthy group, however, the regenerative pulp nerve fibers appeared in the healthy group at 14th day but not be found in the diabetic group. It showed that the regeneration of pulp nerve was later in the diabetic group than that in the healthy group. From the results mentioned above, this study demonstrated that diabetes mellitus influences the reconstruction of the pulp nerve especially during the orthodontic tooth movement. Therefore, it was suggested that diabetes mellitus might play an important role for determining vitality of the dental pulp in clinical diagnosis after orthodontic treatment.
1996-02-25

実験的歯の移動が Streptozotocin 誘発糖尿病ラットの臼歯歯髄内神経線維に及ぼす影響

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