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概要

• 論文の詳細を見る

• Alcohol affects the oculomotor system and postural reflex, and vestibular nuclei are thought to be involved in both. In the medial vestibular nucleus (MVN), alcohol potentiates the effect of T-aminobutylic acid (GABA). Spontaneously firing MVN neurons were examined for alcohol in a brain stem slice. GABA suppressed the spikes evoked by local stimulation in the MVN neuron at the IC50 of 2 mM. One-percent alcohol potentiated the inhibitory effect of GABA, and the IC50 decreased to about 0.3 mM. Acutely dissociated MVN neurons showed similar spontaneous activity. Alcohol (0.01%) also potentiated the inhibitory effect of GABA in this preparation. The vestibular nuclei were particularly sensitive to alcohol in the brain. Therefore, the effect of alcohol is thought to be based on the potentiation of the action of GABA.

• 日本めまい平衡医学会の論文
• 2000-06-01

著者

• 氏原 久充

  高知医科大学神経科精神科学教室

• 氏原 久充

  高知医科大学神経精神医学教室

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