均一系ルテニウム錯体触媒を用いるγ-ブチロラクトンの新規製造法

概要

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γ-Butyrolactone (GBL) is produced by a two-stage hydrogenation of maleic anhydride (MAH) in the liquid phase : a hydrogenation of MAH to succinic anhydride (SAH) in the first stage and a subsequent hydrogenation of SAH to GBL in the second stage. A novel ruthenium catalyst system consisting of Ru salts, trialkylphosphine and <I>p</I>-toluenesulfonic acid (<I>p</I>-TsOH) was found very effective for the hydrogenation of SAH affording GBL in selectivities not less than 95%. Acid promoters like p-TsOH induce structural change in the Ru complexes, leading to the cationic complexes, which show higher catalytic activity and selectivity than the neutral ones. A new process to produce GBL was also developed, in which the features are external preparation of Ru complexes, the reaction protocol which combine over-flow reaction with stripping and the catalyst recovery system by the extraction.
社団法人有機合成化学協会の論文
2000-08-01