Antiischemic Properties of Fasudil in Experimental Models of Vasospastic Angina
スポンサーリンク
概要
- 論文の詳細を見る
We studied the antiischemic properties of fasudil, a Rho-kinase inhibitor, in conscious rabbits with coronary vasospasm induced by vasopressin and endothelin. Pretreatment with fasudil (0.3 and 3 mg/kg) attenuated the maximum elevation of the T-wave elicited by endothelin. Pretreatment with fasudil inhibited the T-wave elevation elicited by vasopressin. Fasudil and hydroxy fasudil, an active metabolite of fasudil, relaxed the endothelin-, U-46619-, 5-hydroxytryptamine- or histamine-induced contraction in swine coronary arterial strips. Fasudil and hydroxy fasudil significantly prevented the reduction in coronary flow by vasopressin in the Langendorff perfused rat heart. Fasudil was effective in protecting the heart against vasopressin and endothelin-induced myocardial ischemic change in conscious rabbits, and this beneficial effect can be attributed to its action of ameliorating the severe contraction of arteries. The inhibition of Rho-kinase may have implications for the development of novel therapeutic strategies for vasospastic angina in patients.
- 社団法人 日本薬理学会の論文
- 2001-09-01
著者
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Shimokawa Hiroaki
Department of Cardiology, Tohoku University School of Medicine
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Satoh S
Scientific Affairs & Sales Promotion Department Asahi Kasei Pharma Corporation
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Shimokawa Hiroaki
Department Of Cardiology Tohoku University School Of Medicine
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Asano T
Institute Of Life Science Research Asahi Kasei Corporation
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Asano Toshio
Laboratory For Pharmacology Asahi Chemical Industry
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Ikegaki Ichiro
Institute Of Life Science Research Asahi Kasei Corporation
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Ikegaki Ichiro
Laboratory For Pharmacology Asahi Chemical Industry
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Satoh S
Institute Of Life Science Research Asahi Kasei Corporation
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Asano Toshio
Institute Of Life Science Research Asahi Kasei Corporation
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SATOH Shin-ichi
Institute of Life Science Research, Asahi Kasei Corporation
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Ikegaki Ichiro
Laboratory For Pharmacology Institute For Life Science Research Asahi Chemical Industry
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