舌癌の増殖能に関する免疫組織化学的研究 : Ki-67 抗原発現と組織学的悪性度との関連性について
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概要
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In the treatment of malignant tumours, estimation of the biological degree of malignancy based on the proliferation potential of tumour cells is now attracting attention. In this study, we tried to clarify the relationship between the growth potency of squamous cell carcinoma of the tongue, which was evaluated by Ki-67 antigen expression, and the histological degree of malignancy or metastasis to the regional lymph nodes: 70 cases of untreated tongue cancer and 19 cases of radical neck dissection were examined immunohistochemically using a monoclonal antibody MIB1. The Ki-67 labeling index (Ki-67 LI) in tongue cancers was significantly higher than that in the normal tongue mucosa, which indicated high cell proliferation activity in the primary lesion of tongue cancer. To study the relation between cell growth and the histological degree of malignancy, the scores of tumour differentiation, histological mode of invasion, and histological degree of malignancy were compared with the proliferative potency of tumour cells. Ki-67 LI was high in poorly differentiated tumours and tumours showing diffuse invasion. When compared with the histological degree of malignancy, Ki-67 LI was high in histologically highly malignant tumours. Among the 70 patients with untreated tongue tumours, 54 patients whose tumours could be classified by the TNM method were selected, and their TNM ranks and cell proliferation activities were compared. However, no statistically significant correlation was noted. In the 19 patients undergoing radical neck dissection, Ki-67 LI in primary lesions of tongue cancer with metastasis to the regional lymph nodes was significantly higher than that in tumours without metastasis.<BR>In summary, immunohistological examination of Ki-67 LI in the primary lesions of tumours is a useful method for understanding the biological degree of malignancy of tumours in clinical practice, and it may be useful in selecting future treatment and evaluating the patients prognosis.
- 社団法人 日本口腔外科学会の論文
- 1995-03-20