Inhibition of Cocaine Sensitization by MK - 801, a Noncompetitive N - Methyl - D - Aspartate (NMDA) Receptor Antagonist: Evaluation by Ambulatory Activity in Mice

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概要

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• Alterations of cocaine effects, which were induced by prior repeated 5-time administration of MK-801 ((+)-5-methyl-10, 11-dihydro-5<I>H</I>-dibenzo[<I>a, d</I>]cyclohepten-5, 10-imine) (i.p.) alone or in combination with cocaine (s.c.) at 3- to 4-day intervals, were investigated by means of ambulatory activity in mice. The repeated administration of either cocaine (10 and 20 mg/kg) alone or MK-801 (0.3 mg/kg) alone progressively enhanced each drugs effect. The enhanced effects of cocaine and MK-801 were estimated to be 1.8-2.2 times and about 1.4 times, respectively, as great as those at the 1st administration. Although the coadministration of MK-801 with cocaine produced a significant enhancement in the ambulation-increasing effect, the comparatively higher doses of MK-801 (0.3 and 1 mg/kg) acted not only to reduce cocaine sensitivity but also to inhibit the development of cocaine sensitization. Thus, the mice that had been given MK-801 (0.3 and 1 mg/kg) alone 5 times showed lower sensitivities to cocaine (20 mg/kg) than the mice given saline alone. The mice coadministered MK-801 (0.3 and 1 mg/kg) with cocaine (10 and 20 mg/kg) also exhibited lower sensitivities to cocaine (10 and 20 mg/kg) than those given cocaine alone. However, MK-801 could not ameliorate the established sensitization to cocaine. Similar interactions have been demonstrated between MK-801 at 1 mg/kg, but not 0.3 mg/kg, and methamphetamine. The present results indicate that MK-801 can inhibit the development of sensitization to cocaine at a lower dose than that required to inhibit methamphetamine sensitization.

• 社団法人 日本薬理学会の論文
• 1995-10-01

著者

• KURIBARA Hisashi

  Department of Neurobiology and Behavior, Behavior Research Institute, Gunma University School of Med

• Asami T

  Gunma Plefectural Sawa Hospital Of Psychiatry

• Asami Takayasu

  Gunma Prefectural Sawa Hospital Of Psychiatry

• IDA Iturou

  Department of Neuropsychiatry, Gunma University School of Medicine

• Kuribara H

  Wakanyaku Medical Inst. Ltd. Gunma Jpn

• Ida Iturou

  Department Of Neuropsychiatry Gunma University School Of Medicine

• Kuribara Hisashi

  Department Of Neurobilogy And Behavior Behavior Research Institute Gunma University School Of Medici

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• EFFECTS OF STYRENE ON WHEEL-RUNNING AND AMBULATORY ACTIVITIES IN MICE
• Modification by MK-801 (Dizocilpine), a Noncompetitive NMDA Receptor Antagonist, of Morphine Sensitization : Evaluation by Ambulation in Mice
• Inhibition of Cocaine Sensitization by MK - 801, a Noncompetitive N - Methyl - D - Aspartate (NMDA) Receptor Antagonist: Evaluation by Ambulatory Activity in Mice
• Haloperidol and Restraint Differently Inhibit the Induction of Sensitization to the Ambulation-Increasing Effect of Methamphetamine in Mice
• Effects of SUN 8399, a Potent and Selective 5-HT1A Agonist, on Conflict Behavior and Ambulatory Activity in Mice: Comparison with Those of Buspirone, Tandospirone and Diazepam.
• Behavioral study on mergocriptine(CBM36-733) by ambulatory activity in mice: Repeated administration and interaction with methamphetamine.
• Characteristics of the Ambulation-Increasing Effect of the Noncompetitive NMDA Antagonist MK-801 in Mice: Assessment by the Coadministration with Central-Acting Drugs.

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