The euryarchaeotes, a subdomain of Archaea, survive on a single DNA polymerase : Fact or farce?

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概要

• 論文の詳細を見る

• Archaea is now recognized as the third domain of life. Since their discovery, much effort has been directed towards understanding the molecular biology and biochemistry of Archaea. The objective is to comprehend the complete structure and the depth of the phylogenetic tree of life. DNA replication is one of the most important events in living organisms and DNA polymerase is the key enzyme in the molecular machinery which drives the process. All archaeal DNA polymerases were thought to belong to family B. This was because all of the products of pol genes that had been cloned showed amino acid sequence similarities to those of this family, which includes three eukaryal DNA replicases and Escherichia coli DNA polymerase II. Recently, we found a new heterodimeric DNA polymerase from the hyperthermophilic archaeon, Pyrococcus furiosus. The genes coding for the subunits of this DNA polymerase are conserved in the euryarchaeotes whose genomes have been completely sequenced. The biochemical characteristics of the novel DNA polymerase family suggest that its members play an important role in DNA replication within euryarchaeal cells. We review here our current knowledge on DNA polymerases in Archaea with emphasis on the novel DNA polymerase discovered in Euryarchaeota.

• 日本遺伝学会の論文
• 1998-12-01

著者

• Cann Isaac

  Department Of Molecular Biology Biomolecular Engineering Research Institute

• Ishino Y

  Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University

• Ishino Yoshizumi

  Department Of Genetic Resources Technology Graduate School Of Bioresource And Bioenvironmental Scien

• Ishino Yoshizumi

  Department Of Bioscience And Biotechnology Graduate School Of Bioresource And Bioenvironmental Scien

関連論文

• The 4^ International Symposium on 3R ; DNA Replicaiton, Recombination and Repair
• Genetic analysis of DNA repair in the hyperthermophilic archaeon, Thermococcus kodakaraensis
• Identification and characterization of Thermus thermophilus HB8 RuvA protein, the subunit of the RuvAB protein complex that promotes branch migration of Holliday junctions
• Identification of the critical region in Replication factor C from Pyrococcus furiosus for the stable complex formation with Proliferating cell nuclear antigen and DNA
• A useful strategy to construct DNA polymerases with different properties by using genetic resources from environmental DNA
• Novel endonuclease in Archaea cleaving DNA with various branched structure
• The euryarchaeotes, a subdomain of Archaea, survive on a single DNA polymerase : Fact or farce?
• The euryarchaeotes, a subdomain of Archaea, survive on a single DNA polymerase:Fact or Farce?
• Genetic analysis of DNA repair in the hyperthermophilic archaeon, Thermococcus kodakaraensis
• 3H1024 P24 Analysis on dynamical structure of intrinsically disordered protein Hef, using MD-SAXS method(3H Protein: Property 4,The 49th Annual Meeting of the Biophysical Society of Japan)
• The OsGEN-L protein from Oryza sativa possesses Holliday junction resolvase activity as well as 5'-flap endonuclease activity

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