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Department of Immunology, Kumamoto University School of Medicine | 論文

• Mouse germinal center B cells with the xid mutation retain responsiveness to antimouse CD40 antibodies but diminish IL-5 responsiveness
• NF-κB is required for CD38-mediated induction of C_γ1 germline transcripts in murine B lymphocytes
• BCR signal through α4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation
• Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas
• Increased expression of germinal center-associated nuclear protein (GANP) is associated with malignant transformation of melanocytes
• Cross-linking of B cell antigen receptorrelated structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphatidylinositol 3-kinase

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