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Department Of Immunohaematology And Blood Bank Leiden University Medical Center University Medical C | 論文

• The generation of SDS-stable HLA DR dimers is independent of efficinet peptide binding
• Definition of agonists and design of antagonists ofr alloreactive T cell clones using synthetic peptide libraries
• Human dendritic cells shed a functional, soluble form of the mannose receptor
• Strongly increased efficiency of altered peptide ligands by mannosylation
• AUTOREACTIVE CD8 T CELLS ASSOCIATED WITH BETA-CELL DESTRUCTION IN TYPE 1 DIABETES
• Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation

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