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Csic Granada Esp | 論文
- Activation-induced apoptosis of mature T cells is dependent upon the level of surface TCR but not on the presende of the CD3ζ ITAM
- Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3ζ
- Expression of a CD3ε transgene in CD3εnull mice does not restore CD3γ and δ expression bur efficienly rescues T cell development from a subpopulation of prothymocytes
- Over-expression of CD3ε transgenes blocks T lymphocyte development
- Selection of peripheral and intestinal T lymphocytes lacking CD3 ζ