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Autoimmunity And Transplantation Division Walter And Eliza Hall Institute Of Medical Research | 論文

• The origin of thymic CD4^+CD25^+ regulatory T cells and their co-stimulatory requirements are determined after elimination of recirculating peripheral CD4^+ cells
• TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death
• Anti-CD45RB antibody deters xenograft rejection by modulating T cell priming and homing
• Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but dues not prevent autoimmune destruction
• Bypassing luminal barriers, delivery to a gut addressin by parenteral targeting elicits local IgA responses
• Targeting CD45RB alters T cell migration and delays viral clearance
• The motif for peptide binding to the insulin-dependent diabetes mellitus-associated class II MHC molecule I-A^ validated by phage display library

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