Yamaguchi Takenori | Department Of Internal Medicine (metabolism And Endocrinology) Graduate School Of Comprehensive Huma
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概要
- YAMAGUCHI Takenoriの詳細を見る
- 同名の論文著者
- Department Of Internal Medicine (metabolism And Endocrinology) Graduate School Of Comprehensive Humaの論文著者
関連著者
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Yamane Teiichi
The Cardiovascular Institute
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Yajima Toshimi
The Cardiovascular Institute Department Of Medicine Keio University School Of Medicine
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YAMASHITA Takeshi
Cardiovascular Institute
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YAMASHITA Takeshi
The Cardiovascular Institute
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Shirao K
Department Of Cardiovascular Surgery National Cardiovascular Center
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Shirao Kuniaki
国立医薬品食品衛生研究所
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Kamakura Shiro
神戸大学 医学部
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Sawada Hitoshi
The Cardiovascular Institute
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SAGARA Koichi
The Cardiovascular Institute
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Yamazaki J
Division Of Cardiovascular Medicine Department Of Internal Medicine Ohmori Hospital Toho University
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Yajima Junji
Department Of Cardiology The Cardiovascular Institute
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SUZUKI Shinya
University of Tokyo
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Kirigaya Hajime
The Cardiovascular Institute
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SATO Hiroshi
The Cardiovascular Institute
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Kasai Satoshi
国立循環器病センター 心臓血管内科
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Ohtsuka Takayuki
The Cardiovascular Institute
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Uejima Tokuhisa
The Cardiovascular Institute
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Oikawa Yuji
The Cardiovascular Institute
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Koike Akira
The Cardiovascular Institute
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Nagashima Kazuyuki
The Cardiovascular Institute
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Uejima Tokuhisa
心臓血管研究所附属病院 循環器科
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Uejima Tokuhisa
心臓血管研究所
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Sagara Kouichi
The Cardiovascular Institute
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Nagashima Kazuyuki
Department Of Cardiology The Cardiovascular Institute
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Yamazaki Junichi
東邦大学医療センター大森病院 循環器内科
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Ogasawara Ken
The Cardiovascular Institute
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AIZAWA Tadanori
The Cardiovascular Institute, Graduate School of Health Sciences Tokyo Medical and Dental University
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Suzuki H
Third Department Of Internal Medicine Showa University School Of Medicine
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Kamakura Shiro
Department Of Cardiovascular Surgery National Cardiovascular Center
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KAMAKURA Shiro
National Cardiovascular Center
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Shirao Kuniaki
国立医薬品食品衛生研究所 薬物応答予測プロジェクト
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DATE Taro
The Cardiovascular Institute
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Ogasawara Ken
Department Of Cardiology The Cardiovascular Institute
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Yamashita Takeshi
Department of Cardiology, Cardiovascular Institution
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Yajima Junji
The Cardiovascular Institute
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小川 聡
国際医療福祉大 三田病院
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小川 聡
慶應義塾大学病院中検
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Yoshimura Michihiro
Department Of Cardiology The Jikei University School Of Medicine
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IIMURA Hiroyuki
The Cardiovascular Institute
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Inoue Hiroshi
富山大学附属病院 神経内科
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Inoue H
The Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Aizawa Tadanori
Department of Cardiology, Cardiovascular Institution
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Inoue H
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Katoh Takao
1st Department Of Internal Medicine Nippon Medical School
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Tanaka K
The First Department Of Internal Medicine Nippon Medical School
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Iinuma Hiroyuki
The Cardiovascular Institute
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IWASAKI Yu-ki
The Cardiovascular Institute
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Date Taro
Department of Cardiology, Jikei University School of Medicine
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Tanaka Keiji
武蔵野赤十字病院
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Oikawa Yuji
Department of Cardiology, The Cardiovascular Institute Hospital
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Kirigaya Hajime
Department of Cardiology, The Cardiovascular Institute Hospital
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Nagashima Kazuyuki
Department of Cardiology, The Cardiovascular Institute Hospital
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Sagara Koichi
Department of Cardiology, The Cardiovascular Institute Hospital
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Koike Akira
Department of Cardiology, The Cardiovascular Institute Hospital
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Sawada Hitoshi
Department of Cardiology, The Cardiovascular Institute Hospital
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Uejima Tokuhisa
Department Of Cardiology The Cardiovascular Institute
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Yoshimura Michihiro
Department of Caldiology Jikei University School of Medisine
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Mizuno Kyoichi
Division Of Cardiology Hepatology Geriatrics And Integrated Medicine Department Of Internal Medicine
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Matsuda Koichi
Department Of Internal Medicine Tokyo Metropolitan Komagome Hospital
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Mizuno Kyoichi
日本医科大学 内科学
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Kamakura Shiro
国立循環器病センター
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Shimazu Yoshihisa
Jikei University School Of Medicine
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Yoshikawa Tsutomu
Division of Cardiology, Department of Medicine, Keio University School of Medicine
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SEKIGUCHI Akiko
The Cardiovascular Institute
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Yamane Teiichi
Department of Cardiology, Jikei University School of Medicine
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YAMAZAKI Tsutomu
University of Tokyo
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MITAMURA Hideo
Saiseikai Central Hospital
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Suzuki Shinya
Department of Clinical Epidemiology & Systems, The University of Tokyo
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Ogasawara Ken
Department of Cardiology, The Cardiovascular Institute Hospital
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Uejima Tokuhisa
Department of Cardiology, The Cardiovascular Institute Hospital
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Ohtsuka Takayuki
Department of Cardiology, The Cardiovascular Institute Hospital
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小川 聡
国際医療福祉大学三田病院
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Miyanaga Satoru
Department of Cardiology, Saitama Cardiovascular Respiratory Center
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Suyama Kazuhiro
国立循環器病センター 心臓血管内科
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Origasa Hideki
Department Of Biostatistics University Of Toyama
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Shirao Kuniaki
Gastrointestinal Oncology Division National Cancer Center Hospital
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Kaji Shuichiro
Department Of Cardiology Kobe City Medical Center General Hospital
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Tokuda Michifumi
Department of Cardiology, The Jikei University School of Medicine
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Miyazaki Hidekazu
Department of Cardiology, The Jikei University School of Medicine
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Suzuki Shinya
The University of Tokyo
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YOSHIDA Hiroshi
Department of Clinical Laboratory Medicine, Fukushima Medical College
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Kijima T
Department Of Internal Medicine (divisions Of Cardiology Hepatology Geriatric And Integrated Medicin
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小川 智
岩手大学工学部応用化学科
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Ogawa Satoshi
心臓血管研究所
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Kawana Masatoshi
Department Of Cardiology Tokyo Women's Medical University
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Yamashita Seigo
Department of Cardiology, Jikei University School of Medicine
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Inada Keiichi
Department of Cardiology, The Jikei University School of Medicine
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Shibayama Kenri
Department of Cardiology, The Jikei University School of Medicine
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Matsuo Seiichiro
Department of Cardiology, The Jikei University School of Medicine
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Sugimoto Kenichi
Department of Cardiology, The Jikei University School of Medicine
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Okumura Ken
Department Of Cardiology Respiratory Medicine And Nephrology Hirosaki University Graduate School Of
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ATARASHI Hirotsugu
Nippon Medical School
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Yamazaki Tsutomu
Department of Clinical Epidemiology & Systems, The University of Tokyo
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Nakamura Michinari
Department of Cardiology, The Cardiovascular Institute Hospital
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ISOBE Mitsuaki
Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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ATARASHI Hirotsugu
Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School
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INOUE Hiroshi
Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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AIZAWA Yoshiharu
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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MIZUNO Kyoichi
Department of Internal Medicine, Nippon Medical School
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Yoshimura Michihiro
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
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Yasutake Masahiro
Division Of Cardiology Department Of Internal Medicine Nippon Medical School
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Yanagisawa Masao
Department Of Internal Medicine Division Of Cardiology Nippon Medical School Tama-nagayama Hosipital
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Takeda Hiroshi
Department Of Medical Information Science Osaka University Graduate School Of Medicine
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Takagi Hiromichi
Department Of Medical Information Science Osaka University Graduate School Of Medicine
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Mizuno Kyoichi
First Department Of Internal Medicine Nippon Medical School
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Kobayashi Yoshinori
Department Of Internal Medicine And Cardiology Tama-nagayama Hospital Nippon Medical School
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Sakurai Masayuki
Hokko Memorial Hospital
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Ito Masahiro
新潟大学 医歯学総合研究科循環器学
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Matsumoto Masayasu
Department Of Clinical Neuroscience And Therapeutics Hiroshima University Graduate School Of Biomedi
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Shirao Kuniaki
国立がんセンター中央病院 消化管内科グループ
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Sai Kimie
Project Team For Pharmacogenetics National Institute Of Health Sciences
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TANABE Hiroaki
The Cardiovascular Institute
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SUMA Hisayoshi
The Cardiovascular Institute
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Umemura S
Department Of Internal Medicine And Cardiorenal Medicine Yokohama City University Graduate School Of
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Kusama Yoshiki
Department Of Internal Medicine And Cardiology Tama-nagayama Hospital Nippon Medical School
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DATE Taro
Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine
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Iwasaki Yuki
Department of Cardiology, Cardiovascular Institution
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Aramaki Yasuko
Department of Cardiology, The Jikei University School of Medicine
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Kanzaki Yasuko
Department of Cardiology, Jikei University School of Medicine
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Abe Kunihiko
Department of Cardiology, The Jikei University School of Medicine
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Okumura Ken
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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KOHSAKA Shun
Keio University School of Medicine
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NAKAYA Haruaki
Chiba University
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FUKATANI Masahiko
Chikamori Hospital
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OGAWA Satoshi
Keio University School of Medicine
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Funada Ryuichi
Department of Cardiology, The Cardiovascular Institute Hospital
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Matsuno Shunsuke
Department of Cardiology, The Cardiovascular Institute Hospital
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Inaba Toshiro
Department of Cardiology, The Cardiovascular Institute Hospital
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Nakagawa Yuya
Department of Cardiology, The Cardiovascular Institute Hospital
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Matsuno Shunsuke
The Cardiovascular Institute Hospital
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Funada Ryuichi
The Cardiovascular Institute Hospital
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Nakamura Michinari
The Cardiovascular Institute Hospital
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Matsubara Mitsunobu
東北大学 医学部遺伝子医療開発分野
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Sugi Kaoru
Division Of Cardiology Toho University
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ORIGASA Hideki
Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine
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HORI Masatsugu
Osaka Medical Center for Cancer and Cardiovascular Disease
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Takano Hitoshi
Division of Cardiology, The First Department of Internal Medicine
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Mizuno Kyoichi
Division of Cardiology, The First Department of Internal Medicine
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SAKU Keijiro
Department of Cardiology, Fukuoka University Hospital
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AIZAWA Yoshifusa
Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences
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Ogawa Satoshi
Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine
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Matsuzaki Masunori
Yamaguchi University Graduate School of Medicine
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Aizawa Yoshifusa
Department of Cardiology, Niigata University Graduate School of Medical and Dental Sciences
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ISHIKAWA Masaya
Department of Internal Medicine, Nippon Medical School
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ASAI Kuniya
Department of Internal Medicine, Nippon Medical School
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Kamakura Shiro
Division of Cardiology, National Cardiovascular Center
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UMEMURA Satoshi
Yokohama City University
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YAMADA Nobuhiro
Department of Internal Medicine, University of Tsukuba
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Umemura S
University Of The Ryukyus
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Umemura Satoshi
熊本大学 医学薬学研究部循環器病態学
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Nozawa Takashi
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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SHIMADA Kazuyuki
Department of Medicine, Jichi Medical University
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Ikeda Takanori
Kyorin University Hospital
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Nozawa Takashi
富山大学 医学薬学研究部第2内科
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Nozawa T
Second Department Of Internal Medicine Toyama Medical & Pharmaceutical University
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Okumura Ken
Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of
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Nagai Takayuki
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Shimamoto K
Department Of Internal Medicine Ii Sapporo Medical University
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Yasuda Yoshinari
National Hospital Organization
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Yui Yoshiki
Division Of Cardiorogy Osaka Red Cross Hospital
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Yasutake Masahiro
Department Of Internal Medicine Division Of Cardiology Nippon Medical School
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Ohashi Yasuo
Department of Biostatistics/Epidemiology and Preventive Health Sciences, School of Health Sciences a
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Nagai Ryouzou
Department of Cardiovascular Medicine, The University of Tokyo
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ITO Makoto
Department of Cardiovascular Medicine, Shiga University of Medical Science
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Kodama Itsuo
Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya Universi
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Matsuzaki Masunori
富山大学 医学部バイオ統計学臨床疫学
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Kodama Itsuo
Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Chinushi Masaomi
School of Health Science, Niigata University School of Medicine
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Umemura Satoshi
日本大学 医学部内科学系腎臓高血圧内分泌内科
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Yazaki Y
Department Of Gene Diagnostics And Therapeutics International Medical Center Of Japan
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Isobe Mitsuaki
Department Of Cardiovascular Medicine Tokyo Medical And Dental University
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Koretsune Yukihiro
Cardiovascular Division, Osaka National Hospital
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SUGI Kaoru
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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KOMUKAI Kimiaki
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine
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TANIGUCHI Ikuo
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine
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IWASAKI Yu-ki
First Department of Internal Medicine, Nippon Medical School
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YAMANE Teiichi
Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine
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ARAMAKI Yasuko
Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine
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Sekiguchi Akiko
Department of Cardiology, Cardiovascular Institution
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Iwasaki Yuki
First Department of Internal Medicine, Nippon Medical School
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Yamashita Seigo
Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine
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Yamashita Syougo
Department of Cardiology, The Jikei University School of Medicine
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Kobayashi Youichi
Third Department of Internal Medicine, Showa University School of Medicine
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Yasuda Yoshinari
大阪大学 医学系研究科老年・腎臓内科学
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Yasuda Yoshinari
大阪大学 医学系研究科保健学専攻検査情報学研究室
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Yasuda Yoshinari
Department Of Clinical Immunology Nagoya University Graduate School Of Medicine
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Yamada Nobuhiro
The Research Committee For Primary Hyperlipidemia Research On Measures For Intractable Diseases By T
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Nagai Ryouzou
Department Of Cardiovascular Medicine Graduate School Medicine University Of Tokyo
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Takahashi Nobuki
Department Of Clinical Studies And Genetics Radiation Effects Research Foundation
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AIZAWA Yoshiyasu
Keio University School of Medicine
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Yamazaki Tsutomu
The University of Tokyo
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Ohe Tohru
Cardiovascular Medicine, Okayama University
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Okumura Ken
Cardiology, Hirosaki University
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Aizawa Yoshifusa
First Department of Internal Medicine, Niigata University School of Medicine
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Ohara Takahiro
国立循環器病センター 心臓血管内科
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Ikeda Takanori
The Second Department Of Internal Medicine Kyorin University School Of Medicine
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Ikeda Takanori
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Sumitomo Naokata
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Nitta Takashi
Division Of Cardiovascular Surgery Nippon Medical School
著作論文
- Recruitment of Immune Cells Across Atrial Endocardium in Human Atrial Fibrillation
- Infiltration of Macrophages Through the Atrial Endocardium of Inflammation-Induced Rats : Contribution of Fractalkine
- PJ-565 Aging-related Regional Inhomogeneities in Macrophage Infiltration and Interstitial Fibrosis in Rat Atria(PJ095,Arrhythmia, Others (Basic) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-435 Promotion of Macrophage Infiltration and Interstitial Fibrosis in Diabetic Rat Atria(PJ073,Arrhythmia, Others (Basic) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-294 Fibrillatory Cycle Length Prolongation on Surface Electrocardiogram by Pulmonary Vein Isolation : Role of Pulmonary Vein in Persistent Atrial Fibrillation Patients(PJ050,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 4 (A),Poster Session (Japane
- PJ-153 Lower Prevalence of Dissociated Activity in Isolated Pulmonary Veins according to the Progression of Atrial Fibrillation(PJ026,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meetin
- PE-290 Impact of Prolongation of Atrial Fibrillatory Cycle Length on Catheter Ablation Results in Long-Lasting Persistent Atrial Fibrillation(PE049,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) 2 (A),Poster Session (English),The 73rd Annual Scie
- Comparison of Antiarrhythmics Used in Patients With Paroxysmal Atrial Fibrillation : Subanalysis of J-RHYTHM Study
- PJ-321 The Relationships between Urinary Albumin and Prevalence of Cardiac Diseases in Japanese Patients(PJ054,Kidney/Renal Circulation/CKD 3 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-536 The Relationships between BNP and AF in Japanese Patients(PE090,Heart Failure (Biomarker) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- Body Size and Atrial Fibrillation in Japanese Outpatients
- PJ-691 Role of Low EF in Prognosis of Japanese Patients with Ventricular Tachycardia : Comparison with Preserved EF(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
- PJ-147 The Role of Atrial Fibrillation in Prognosis in Japanese Patients with Acute Coronary Syndrome(PJ025,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- PJ-077 Association between Left Atrial Dimension and Prognosis in Japanese Patients with Cardiovascular Diseases(PJ013,Cardiac Function (Clinical) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-462 Impact of Albuminuria on Coronary Artery Disease(PE078,Angina Pectoris (Clinical) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-281 Impact of Drug-Eluting Stent for Coronary Artery Disease on Mortality and Morbidity(PE047,Coronary Revascularization, PCI (DES) 4 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Impact of reduced renal function on prognosis in Japanese patients with coronary artery disease : a prospective cohort of Shinken Database 2007
- PJ-564 Distribution of Collagen, Macrophages and Fibroblasts in Human Atria with Atrial Fibrillation(PJ095,Arrhythmia, Others (Basic) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Impact of Drug Alteration to Maintain Rhythm Control in Paroxysmal Atrial Fibrillation : Subanalysis From J-RHYTHM Study
- PJ-605 The Latest Clinical Outcomes of Massive Pulmonary Embolism in the Tokyo CCU Network(PJ102,Pulmonary Circulation 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-076 Importance of Systolic Blood Pressure in Acute Heart Failure Syndromes : Relationship between Forrester's Classification and Clinical Scenarios(PJ013,Cardiac Function (Clinical) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of
- PE-440 The Incidence of Perioperative Complete Atrioventricular Block Associated with Percutaneous Transluminal Septal Myocardial Ablation and the Indication of Permanent Pacemaker(PE074,Cardiomyopathy/Hypertrophy (Clinical) 2 (M),Poster Session (English)
- Dose-Response Effects of Bepridil in Patients With Persistent Atrial Fibrillation Monitored With Transtelephonic Electrocardiograms : A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study (J-BAF Study)
- EFFECTS OF CAPTOPRIL (CP) ON THE SYSTEMIC, CEREBRAL AND RENAL HEMODYNAMICS OF HYPERTENSIVE PATIENTS : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
- PE-443 Clinical Characteristics of Spontaneous Occurring Ventricular Tachyarrhythmia following PTSMA in Patients with HOCM(PE074,Cardiomyopathy/Hypertrophy (Clinical) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circul
- FRS-102 Event rates of Japanese patients with atherothrombosis : Results from the REduction of Atherothrombosis for Continued Health (REACH) Registry(Clinical Frontiers in Atherosclerosis(IHD),Featured Research Session,The 72nd Annual Scientific Meeting o
- Cilostazol Stroke Prevention Study : A Placebo-Controlled Double-Blind Trial for Secondary Prevention of Cerebral Infarction
- Lipoprotein (a) in Ischemic Heart Disease and Cerebrovascular Disease
- Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008) : Digest Version
- Heart failure with preserved versus reduced left ventricular systolic function : A prospective cohort of Shinken Database 2004-2005
- Clinical outcome after acute coronary syndrome in Japanese patients : An observational cohort study
- A Case of Adenosine Sensitive Atrial Tachycardia Originating from the His-Bundle Region Successfully Ablated from the Non-coronary Aortic Cusp
- Brachial-ankle pulse wave velocity as a risk stratification index for the short-term prognosis of type 2 diabetic patients with coronary artery disease
- Investigation of optimal anticoagulation strategy for stroke prevention in Japanese patients with atrial fibrillation : The J-RHYTHM Registry study design
- Present Status of Anticoagulation Treatment in Japanese Patients With Atrial Fibrillation : A Report From the J-RHYTHM Registry
- Antithrombotic Therapy in Atrial Fibrillation : Evaluation and Positioning of New Oral Anticoagulant Agents
- Lacunar Syndrome Associated with Paradoxical Brain Embolism
- Guidelines for Risks and Prevention of Sudden Cardiac Death (JCS 2010) : Digest Version
- Distribution of First-Detected Atrial Fibrillation Patients Without Structural Heart Diseases in Symptom Classifications
- Dabigatran in Clinical Practice for Atrial Fibrillation With Special Reference to Activated Partial Thromboplastin Time
- Gender-Specific Relationship Between Serum Uric Acid Level and Atrial Fibrillation Prevalence
- Novel approach to ischemic skin ulcer in systemic lupus erythematosus : Therapeutic angiogenesis by controlled-release basic fibroblast growth factor
- Randomized, Multicenter, Warfarin-Controlled Phase II Study of Edoxaban in Japanese Patients With Non-Valvular Atrial Fibrillation
- Simultaneous Fenestration with Stent Implantation for Acute Limb Ischemia due to Type B Acute Aortic Dissection Complicated with Both Static and Dynamic Obstructions
- Electrocardiography Characteristics of Isolated Non-Compaction of Ventricular Myocardium in Japanese Adult Patients